S. Takasu, M. Ariizumi, S. Matsumoto, Y. Kanto, K. Iwadate
Abstract: Coronavirus disease 2019 (COVID-19) is a disease that is caused by the SARS-CoV-2 virus. Despite the fact that COVID-19 may also have a relationship with aortic dissection, more research is required to confirm this coherence. A 47-year-old man with no medical history was found dead at his home. Before passing away, he showed coughing symptoms. Postmortem computed tomography revealed the aortic wall of the Valsalva sinus underneath the entrance of the left main trunk of the coronary artery had thickened. At the time of autopsy, laceration was seen in the Valsalva sinus’s intimal layer, right beneath the entry of the left main trunk of the coronary artery, and the dissection was localized from the Valsalva sinus to the anterior descending coronary artery. Histologically, medial necrosis was observed in the arterial media only near the false lumen. The RT-qPCR test for SARS-CoV-2 was positive even though the fast antigen tested negative. Aortic dissection- induced myocardial infarction was determined to be the cause of death. Although undiagnosed hypertension could have contributed to aortic dissection, the association of SARS-CoV-2 was proposed due to the lack of medical history and the localization of the medial necrosis at the dissection site. Keywords: COVID-19, SARS-CoV-2, aortic dissection, myocardial infarction, forensic pathology.
 is a disease that is caused by the SARS-CoV-2 virus. Despite the fact that COVID-19 may also have a relationship with aortic dissection, more research is required to confirm this coherence. A 47-year-old man with no medical history was found dead at his home. Before passing away, he showed coughing symptoms. Postmortem computed tomography revealed the aortic wall of the Valsalva sinus underneath the entrance of the left main trunk of the coronary artery had thickened. At the time of autopsy, laceration was seen in the Valsalva sinus’s intimal layer, right beneath the entry of the left main trunk of the coronary artery, and the dissection was localized from the Valsalva sinus to the anterior descending coronary artery. Histologically, medial necrosis was observed in the arterial media only near the false lumen. The RT-qPCR test for SARS-CoV-2 was positive even though the fast antigen tested negative. Aortic dissection- induced myocardial infarction was determined to be the cause of death. Although undiagnosed hypertension could have contributed to aortic dissection, the association of SARS-CoV-2 was proposed due to the lack of medical history and the localization of the medial necrosis at the dissection site.&redirect_uri=http://rjlm.ro/index.php/arhiv/989)