Bile as a complementary matrix for methamphetamine testing, an autopsy case of methamphetamine poisoning
H. Kinoshita, A. Takakura, M. Kumihashi, M. Jamal, K. Tsutsui, S. Kimura, K. Ameno, S. Matsubara, N. Tanaka
Abstract: We present a fatality due to methamphetamine abuse. Quantitative toxicological analysis showed that the concentrations of methamphetamine (MA) and its metabolite, amphetamine (AM) in the femoral blood were 5.51 μg/mL and 0.22 μg/mL, respectively. MA concentrations in other fluids were as follows: cerebrospinal fluid, 7.56 μg/mL; pericardial fluid, 5.81 μg/mL; urine, 400.72 μg/mL; bile, 18.49 μg/mL; and stomach contents, 159.55 μg/mL, respectively. We concluded that the cause of death was due to MA poisoning. Because the MA concentration in bile is relatively high, we propose that its measurement may be a useful indicator for MA use, in addition to its detection in urine. Keywords: bile, methamphetamine, abuse, alternative specimen.
 and its metabolite, amphetamine (AM) in the femoral blood were 5.51 μg/mL and 0.22 μg/mL, respectively. MA concentrations in other fluids were as follows: cerebrospinal fluid, 7.56 μg/mL; pericardial fluid, 5.81 μg/mL; urine, 400.72 μg/mL; bile, 18.49 μg/mL; and stomach contents, 159.55 μg/mL, respectively. We concluded that the cause of death was due to MA poisoning. Because the MA concentration in bile is relatively high, we propose that its measurement may be a useful indicator for MA use, in addition to its detection in urine.&redirect_uri=http://rjlm.ro/index.php/arhiv/767)