<- Home <- Arhive <- Vol. 27, Issue 2, June 2019



Rom J Leg Med27(2)200-204(2019)
DOI:10.4323/rjlm.2019.200
© Romanian Society of Legal Medicine


The impact of replacement therapy on dental health in haemophilia

A. Kozma, O. Clevet, A. Traila, E. Ursu, C. Jinca, R. Oancea, E. Boeriu, E. Boia, L. Ritli, M. Șerban, A. K. Lackner, H. Lăzărescu, C. Popovici, I. Diac, A. M. A. Stănescu, C. Enachescu, S. Arghirescu


Abstract: Aim. To evaluate the dental health status and its relationship with the replacement therapy in persons with haemophilia (PwH). Material and methods. In this descriptive non-interventional cross-sectional study we included a number of 47 patients, divided in 2 distinct age groups: 12 patients under- and 35 above 18 years of age. Demographic information, laboratory findings and dental health status were recorded in a standard form. Dental health was evaluated by means of the decay –missing- filling teeth (DMFT) index and plaque index (PLI); these parameters were correlated with the quality of replacement therapy and compared to a matched control group. Results and discussions. The image offered by our descriptive cross-sectional study revealed a dental status in hemophilic children comparable with that of the children from the matched control group. On the contrary, adult PwH have a dismal DMFT and PLI indexes; they are in significant correlations with the quantity and frequency of replaced coagulation factors. Conclusions. The findings highlight the need of comprehensive oral examinations including preventive dental treatment and follow-up care in the PwH connected to an adequate replacement therapy.
Keywords: pharmacologic replacement therapy, coagulation factor VIII and IX concentrates, haemophilia, dental health, DMFT index, PLI index.



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