<- Home <- Arhive <- Vol. 26, Issue 4, December 2018

Rom J Leg Med26(4)333-339(2018)
© Romanian Society of Legal Medicine

Autophagy as a neuronal survival mechanism in ischemic stroke

B. I. Coculescu, G. Manole, E. C. Coculescu, E. Ionescu, O. Popoviciu, C. M. Stocheci

Abstract: Based on the histological examination of the encephalic fragments collected during the necropsy of 38 patients who died from ischemic stroke, the authors admit that the ischemic tolerance phenomena that are described as particular to transient ischemic strokes are also present in the peripheral areas of the core of a cerebral infarction. This marginal area called the penumbra area has the characteristic that the ischemia did not exceed the critical threshold so that neuronal necrosis can occur. As a result, the metabolism of these neurons proceeds under the conditions of a critical supply and becomes responsible for the characteristics of the nucleo-cytosolic environment. Consequently, modified intracellular environments induce the alteration of their form that is histochemically expressed, nucleocytosolic, changing, among other things, the coloration, hence the name of red neurons. Etiopathogenic, the changes are based on the installation of oxidative stress, but also the possibility of autophagy installation, as a form of neuronal survival, expressed clinically by reducing the sensory-motor deficit of the patient.
Keywords: stroke (AVC), red neurons, neuronal hypoxia, oxidative stress, autophagocytosis.

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