<- Home <- Arhive <- Vol. 26, Issue 2, June 2018

Rom J Leg Med26(2)103-111(2018)
© Romanian Society of Legal Medicine

Phenotypical transformations of neurovascular structures in amygdaloid neuronal complex in senescent people. Implications in forensic psychopatology

I. Marinescu, P. R. Melinte, I. Dincă, E. Pătrașcu, M. I. B. Meșină, G. SDrăgoi,

Abstract: The progress of knowledge regarding the functional anatomy of amygdaloid neuronal complex structures, discovered in 1819 by Karl Friederich Burdach, has been very intense in the last 95 years due to frequent research-work performed on lab animals, but very seldom on man. In the present work, we aim at evaluating the phenotypical transformations of neurons, blood vessels and microglia in human biological material in senescence. The investigation was performed on ten human encephala drawn from senescent subjects, 6 men (aged 68 to 80) and 4 women (aged 69 to 80). The study was carried out by the forensic pathologist using specific tools, in two successive stages: macroscopy and microscopy. In the macroscopic stage, we were interested in the access pathways in order to visualize the location and evaluation of the amygdaloid neuronal system. Microanatomy studies were based on the double nature of neuron – interstitium and their biunivocal partnership. In our casuistics we have identified two partnership systems: between neurons and microglial cells on the one hand, and blood vessels and microglial cells on the other. We noticed that the ”microglial cell structure” is the common factor in the two partnership systems. This evidence shows the part played by microglial cells in processes of phenotypical transformations of neurons and blood cells, with obvious implications in psychopathology.
Keywords: amygdaloid neuronal complex, microglia, hemato-encephalic barrier, neuron degenerescence, senescence, Alzheimer’s disease.

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