<- Home <- Arhive <- Vol. 16, Issue 2, June 2008

Rom J Leg Med16(2)95-102(2008)
© Romanian Society of Legal Medicine

Practical implications of GC and HPLC methods for the analysis of drugs of abuse in blood

C. Dogaroiu, R. Sugden

Abstract: Rapid trace level quantitative determination of drugs and their metabolites is a challenge which is often driven by the need for same-day turn around of results for an increasing number of biological samples. This article reviews and compares GC and HPLC methods for the analysis of some important drugs of abuse, their metabolites and adulterants (cocaine, LSD, ketamine, benzodiazepines, strychnine) in blood, presenting the benefits and limitations of each method. It also outlines which of the two procedures is more suitable for general blood analysis performed when the drugs in the sample are unknown, as is often the case in the police work.
Keywords: drugs of abuse, blood samples, GC, HPLC.

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