<- Home <- Arhive <- Vol. 23, Issue 3, September 2015



Rom J Leg Med23(3)157-162(2015)
DOI:10.4323/rjlm.2015.157
© Romanian Society of Legal Medicine


A case of variant Creutzfeldt-Jakob disease in Romania

M. Ceau┼ču, C. O. Capatina, S. Hostiuc, D. Dermengiu


Abstract: In humans prion diseases can occur sporadically, through genetic mutations, or can be transmitted from animal, human (kuru disease), or iatrogenic sources. Even though transmissible forms are the most well-known, the sporadic and heritable forms are much more frequent, accounting for about 85% of all cases. The purpose of this case report is to present an atypical variant CJD in a 26 years-old woman. The patient died secondary to infectious complications caused by an acute overdose with alcohol, beta-blockers and oral anti-diabetic drugs, and had an atypical neuropathology pattern, with absent amyloid plaques, but present focal, perivascular deposits of amyloid precursor protein and a positive immunohistochemical reaction for prp.
Keywords: variant Creutzfeldt-Jakob disease, Romania, amyloid precursor protein.



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