A case of variant Creutzfeldt-Jakob disease in Romania
M. Ceauşu, C. O. Capatina, S. Hostiuc, D. Dermengiu
Abstract: In humans prion diseases can occur sporadically, through genetic mutations, or can be transmitted from
animal, human (kuru disease), or iatrogenic sources. Even though transmissible forms are the most well-known, the sporadic and
heritable forms are much more frequent, accounting for about 85% of all cases. The purpose of this case report is to present an
atypical variant CJD in a 26 years-old woman. The patient died secondary to infectious complications caused by an acute overdose
with alcohol, beta-blockers and oral anti-diabetic drugs, and had an atypical neuropathology pattern, with absent amyloid plaques,
but present focal, perivascular deposits of amyloid precursor protein and a positive immunohistochemical reaction for prp. Keywords: variant Creutzfeldt-Jakob disease, Romania, amyloid precursor protein.
, or iatrogenic sources. Even though transmissible forms are the most well-known, the sporadic and
heritable forms are much more frequent, accounting for about 85% of all cases. The purpose of this case report is to present an
atypical variant CJD in a 26 years-old woman. The patient died secondary to infectious complications caused by an acute overdose
with alcohol, beta-blockers and oral anti-diabetic drugs, and had an atypical neuropathology pattern, with absent amyloid plaques,
but present focal, perivascular deposits of amyloid precursor protein and a positive immunohistochemical reaction for prp.&redirect_uri=http://rjlm.ro/index.php/arhiv/428)