<- Home <- Arhive <- Vol. 18, Issue 3, September 2010

Rom J Leg Med18(3)193-198(2010)
© Romanian Society of Legal Medicine

Fatal anaphylaxis in the presence of eosinophilic pneumonia in an asthmatic patient. A case report

M. Liang, A. Sunnassee, L. Yan, N. Zheng, L. Zhuo, Z. Haidong, L. Liang

Abstract: Eosinophilic pneumonia (EP) is a rare allergic syndrome. It has been subdivided into two types including acute eosinophilic pneumonia and chronic eosinophilic pneumonia. The pathology of EP is usually characterized by diffuse eosinophilic granulocyte infiltration in the lungs. We present the unusual case of a 39-year-old woman who died unexpectedly in hospital. She had a previous history of asthma and repeated hospital admissions. A fatal asthmatic attack was initially opined as the cause of death but autopsy disclosed that she died of anaphylactic shock in the presence of EP. Microscopic examination of organs and tissues showed eosinophilic granulocyte infiltration not only in the lungs, but also in the splenic sinuses, gastric mucosa and at the injection site on the skin of the dorsum of the hand. Patients with EP very rarely show eosinophilic granulocytes infiltration in locations other than the lungs. Her hypersensitive diasthesis, injection infusion of a combination of a traditional Chinese drug and western drug and the presence of EP were together contributed to anaphylaxis and death.
Keywords: Eosinophilic pneumonia, Anaphylactic shock, Eosinophilic granulocyte, Forensic pathology

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